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 Optimized Surgical Techniques in Laparoscopic Living-Donor Right Hemihepatectomy Using Indocyanine Green Fluorescence Images
YoungRok Choiorcid, Suk Kyun Hongorcid, Nam-Joon Yiorcid, Kwang-Woong Leeorcid, Kyung-Suk Suhorcid
Journal of Surgical Innovation and Education 2024;1(1):14-17.
DOI: https://doi.org/10.69474/jsie.2024.00066
Published online: June 24, 2024

Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea

Corresponding author: YoungRok Choi, MD Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea Tel: +82-2-2072-4318, E-mail: 'choiyoungrok@gmail.com'
• Received: June 15, 2024   • Revised: June 19, 2024   • Accepted: June 19, 2024

© 2024 Korean Surgical Skill Study Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • This paper outlines the surgical technique for laparoscopic living-donor right hemihepatectomy (LLDRH), a minimally invasive procedure that increases graft safety and reduces donor morbidity. The technique includes careful patient selection, precise port placement, meticulous liver mobilization, and careful parenchymal dissection, followed by secure graft extraction and effective hemostasis. LLDRH offers several advantages over open living-donor surgery, including lower costs, less postoperative pain, shorter hospital stays, and better cosmetic results. The use of advanced three-dimensional laparoscopic systems and indocyanine green fluorescence imaging has further increased the safety and effectiveness of this procedure. As laparoscopic technology continues to evolve, LLDRH is likely to become more widely adopted, offering a valuable option for liver transplantation programs. A video clip shows a 32-year-old woman with a body mass index of 25.7 kg/m2 who donated her right liver. Her remnant liver volume was 34%, and the estimated graft-to-recipient weight ratio was 1.2. The operation time was 240 minutes, with an estimated blood loss of 150 mL. She was discharged on the fifth postoperative day without any complications.
  • Keywords: Laparoscopy, Liver transplantation, Living donors, Hepatectomy, Minimally invasive surgical procedures, Indocyanine green
The growing expertise in laparoscopic techniques has made laparoscopic living-donor right hemihepatectomy (LLDRH) a viable option for liver transplantation programs [1-3]. Advancements in laparoscopic equipment, such as the use of three-dimensional laparoscopic systems and laparoscopic energy devices—including ultrasound devices, cavitron ultrasonic surgical aspirator (CUSA), and bipolar devices—have improved the precision and safety of LLDRH. Consequently, LLDRH has emerged as a significant advancement in minimally invasive liver surgery, ensuring both graft safety and viability. Living donors benefit from reduced postoperative pain, shorter hospital stays, and better cosmetic outcomes compared to those undergoing open donor hepatectomy. We outline the basic surgical techniques used in LLDRH [4]. All surgical procedures performed by the operator and first assistant are described in a supplementary document (Supplementary Material 1).
A 32-year-old woman donated her right liver to a family member. Her weight was 65.3 kg and her height was 159.3 cm, resulting in a body mass index of 25.7 kg/m2. Based on computed tomography (CT) volumetry, the future remnant liver volume was estimated as 34%, and the estimated graft-to-recipient-weight ratio was 1.2. CT showed that she had conventional anatomy of the hepatic artery (HA) and the hepatic vein (HV), as well as trifurcation-type portal vein (PV) anatomy. Magnetic resonance imaging revealed a fat fraction of 3.5% and typical bile duct (BD) anatomy. The operation time was 240 minutes, with an estimated blood loss of 150 mL. She was discharged on the fifth postoperative day without any complications. The Institutional Review Board of Seoul National University Hospital approved this study (2406-037-1542).
Patient selection
Careful donor selection is crucial for LLDRH. Suitable donors are healthy adults with typical vascular and BD anatomy. A single right HA, a single right PV, and a single right BD without a significantly sized right inferior HV are preferred because complex vascular and BD variations increase the risk of complications. The right liver graft should be 0.8% to 1.5% of the recipient’s body weight, and the remnant liver volume should exceed 30%.
Preparations
The donor was positioned supine with legs split and straightened, in a reverse Trendelenburg position at 15° with a left tilt. To prevent movement as the bed position changed, the patient was secured. An operator stood between the donor’s legs, while the first assistant and a scopist were positioned on the patient’s left side.
Port placement
A trans-umbilical port was utilized for the camera, while the operator's two working ports were positioned approximately 30° away from the center of the liver. The other two ports were for an assistant.
Liver mobilization
After resecting the falciform ligament up to the inferior vena cava (IVC) and the right coronary ligament, the inferior portion of the right liver was detached from the right hepatorenal ligament. Care was taken to gently separate the right adrenal gland from the liver to minimize the risk of bleeding. A space was created between the liver and the IVC, during which the short HVs and the small right inferior HVs were also excised. The large right inferior HV was resected just prior to the extraction of the liver.
Hilar dissection
The cystic duct was left long and used for traction to expose the right PV and right HA. After temporarily clamping the right HA and the right PV, indocyanine green (ICG) was administered intravenously. The parenchymal resection line was then marked along the boundary indicated by the fluorescence images of the left liver.
Parenchymal dissection
The traction method is not always necessary, but it is helpful for large livers. Both parenchymal sides of the resection line were retracted by pulling a rubber band from outside the abdominal cavity. Liver parenchymal dissection was performed using an ultrasound device, CUSA, and a bipolar device. The segment 5 (V5) branches and the segment 8 branches (V8) branches of the middle HV (MHV) were temporarily ligated with plastic clips. The resection plane was followed along the right side of the MHV. The caudate process and remaining liver parenchyma above the IVC were transected after dividing the right BD under ICG fluorescence imaging. A hanging maneuver using a tube or an instrument was useful for facilitating the parenchymal dissection and reducing bleeding. The hilar plate was transected, leaving only the right PV and right HA in the hilum.
Graft extraction
A vinyl bag containing the right liver graft was removed through the Pfannenstiel incision following a longitudinal incision on the abdominal wall. This procedure was performed after dividing the right HA and applying staples to the right PV and HV. Additionally, the right IVC ligament was resected using a staple.
Hemostasis and fixation
A closed suction drain was positioned near the resection site to monitor bleeding and bile leakage. To prevent vascular torsion and ensure correct positioning, the remaining left liver was secured with sutures anchored to the remnant falciform ligaments.
Open hepatectomy has long been the standard approach in living donor surgery, providing direct visualization and facilitating easier manipulation of the liver. However, this method is associated with higher morbidity, including significant postoperative pain, extended hospital stays, and larger scars. Robotic living donor hepatectomy, a newer technique, offers enhanced dexterity, precision, and a three-dimensional view of the operative field. It shares the benefits of minimally invasive surgery with laparoscopic living donor hepatectomy, such as reduced postoperative pain and quicker recovery [5,6]. However, robotic surgery incurs high costs and requires specialized training and equipment, which may limit its accessibility.
LLDRH offers the advantages of minimally invasive surgery, and a postoperative complication rate comparable to that of open donor right hemihepatectomy. These benefits have contributed to its widespread adoption and greater accessibility compared to robotic surgery. The use of flexible high-definition three-dimensional laparoscopic systems and ICG fluorescence imaging has significantly improved the precision and safety of LLDRH [7]. Additionally, these tools assist in the clear identification of vascular and biliary structures, thereby minimizing the risk of intraoperative complications [4].
As laparoscopic techniques continue to advance, the adoption of LLDRH is expected to grow [8,9]. Additionally, ongoing training programs and the accumulation of experience will enable surgeons to overcome the technical challenges associated with LLDRH.
Supplementary Marterial 1.
Surgical procedures.
jsie-2024-00066-Supplementary-Marterial-1.pdf

Disclosure

No potential conflict of interest relevant to this article was reported.

Acknowledgments

All authors would like to thank Hyeon Su Kang from the liver team at Seoul National University Hospital for his hard work editing the video. Hnin Aye Yin and Pham Hai Trieu described the procedures performed by surgeons in laparoscopic living-donor right hemihepatectomy. This manuscript was proofread in English using ChatGPT-4o.

Author contributions

Conceptualization: YRC, KWL, KSS; Data curation: YRC, SKH, NJY; Writing–original draft: YRC; Writing–review & editing: YRC, SKH, NJY, KWL, KSS; Video-review: YRC, SKH, NJY, KWL, KSS.

Video.
 
  • 1. Han HS, Cho JY, Yoon YS, Hwang DW, Kim YK, Shin HK, et al. Total laparoscopic living donor right hepatectomy. Surg Endosc. 2015;29:184.ArticlePubMedPDF
  • 2. Komatsu S, Scatton O, Goumard C, Sepulveda A, Brustia R, Perdigao F, et al. Development process and technical aspects of laparoscopic hepatectomy: learning curve based on 15 years of experience. J Am Coll Surg. 2017;224:841-850.ArticlePubMed
  • 3. Han HS, Cho JY, Kaneko H, Wakabayashi G, Okajima H, Uemoto S, et al. Expert panel statement on laparoscopic living donor hepatectomy. Dig Surg. 2018;35:284-288.ArticlePubMedPDF
  • 4. Hong SK, Choi Y, Yi NJ, Lee KW, Suh KS. Insights from Seoul National University Hospital’s experience: a systematic review of pure laparoscopic donor hepatectomy progression. Hepatobiliary Surg Nutr. 2024;13:293-300.ArticlePubMedPMC
  • 5. Broering D, Sturdevant ML, Zidan A. Robotic donor hepatectomy: a major breakthrough in living donor liver transplantation. Am J Transplant. 2022;22:14-23.ArticlePubMedPDF
  • 6. Kim NR, Han DH, Choi GH, Lee JG, Joo DJ, Kim MS, et al. Comparison of surgical outcomes and learning curve for robotic versus laparoscopic living donor hepatectomy: a retrospective cohort study. Int J Surg. 2022;108:107000.ArticlePubMed
  • 7. Hong SK, Lee KW, Kim HS, Yoon KC, Ahn SW, Choi JY, et al. Optimal bile duct division using real-time indocyanine green near-infrared fluorescence cholangiography during laparoscopic donor hepatectomy. Liver Transpl. 2017;23:847-852.ArticlePubMedPDF
  • 8. Hong SK, Suh KS, Kim HS, Yoon KC, Ahn SW, Oh D, et al. Pure 3D laparoscopic living donor right hemihepatectomy in a donor with separate right posterior and right anterior hepatic ducts and portal veins. Surg Endosc. 2017;31:4834-4835.ArticlePubMedPDF
  • 9. Rhu J, Kim MS, Choi GS, Kim JM, Kwon CHD, Joh JW. Laparoscopic living donor right hepatectomy regarding the anatomical variation of the portal vein: a propensity score-matched analysis. Liver Transpl. 2021;27:984-996.ArticlePubMedPDF

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        Optimized Surgical Techniques in Laparoscopic Living-Donor Right Hemihepatectomy Using Indocyanine Green Fluorescence Images
        J Surg Innov Educ. 2024;1(1):14-17.   Published online June 26, 2024
        DOI: https://doi.org/10.69474/jsie.2024.00066
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